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FLASH GENE
Symbol DCLK1 contributors: mct/npt - updated : 25-01-2023
HGNC name doublecortin-like kinase 1
HGNC id 2700
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in many cancers including colorectal cancer (CRC)
tumoral     --over  
may be responsible for the increased metastatic features in breast cancer cells
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • DCLK1 may serve as an independent predictor for Colo-rectal cancer prognosis
  • evaluating high serum DCLK1 is a biomarker for detection of hepatocellular carcinoma (HCC)
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    therapeutic target for eradicating HCC
    cancerdigestivecolon
    potential therapeutic target for the treatment of colorectal cancer
    cancerbrainglioma/neuroblstoma
    silencing DCLK1 induces apoptosis in NB cells
    cancerdigestivecolon
    potential for developing a therapy for colorectal cancer based on targeting DCLK1-positive tumor stem cells (TSCs)
    cancer  
    potential anti‑tumor target via the glucose metabolism pathway
    immunologyinfectious 
    DCLK1 could be a potential therapeutic target for COVID-19, especially in patients with underlying comorbid diseases associated with DCLK1 expression
    cancerreproductivebreast
    targeting DCLK1 may become a therapeutic option for breast cancer metastasis
    ANIMAL & CELL MODELS
  • mice with a targeted disruption of Dcamkl1 displayed elevated bone mass secondary to increased bone formation by osteoblasts