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FLASH GENE

Symbol

ADAMTS3

contributors: npt/ - updated : 14-11-2006

HGNC name	ADAM metallopeptidase with thrombospondin type 1 motif, 3
HGNC id	219

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	288.00 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed ADAMTS3 22 - 5821 135.6 1205 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Visual eye retina

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal sequence
	a propeptide domain
	a reprolysin-type catalytic domain
	a disintegrin-like domain
	a thrombospondin type 1 (TSP1) module
	a cysteine rich domain
	a spacer domain without cysteine residues
	three terminal TSP-like modules

conjugated

MetalloP

isoforms

Precursor

HOMOLOGY

Homologene

FAMILY

ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	a disintegrin-like and metalloprotease activity
	cell surface adhesion protein
	pro-collagen N-propeptidase activity

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS