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FLASH GENE

Symbol

ZBTB5

contributors: mct/npt - updated : 04-11-2009

HGNC name	zinc finger and BTB domain containing 5
HGNC id	23836

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014872 2 - 4654 74.15 677 - Gerhard (2004)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine small intestine       Lymphoid/Immune tonsils       highly Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one BTB/POZ domain
	two C2H2-type zinc fingers

HOMOLOGY

interspecies

ortholog to murine Zbtb5

Homologene

FAMILY

kruppel family of C2H2-type zinc-finger proteins

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	localized to the nucleus, particularly nuclear speckles (Koh 2009)

basic FUNCTION	involved in the regulation of transcription, DNA-dependent
	may be an important transcription regulator of CDKN1A and may play a critical role in regulating important biological processes controlled by CDKN1A (Koh 2009)
	recriuting corepressor-HDACs to deacetylate the histones of nearby nucleosomes around the proximal promoter (Koh 2009)
	potently stimulates cell growth and increases the number of cells in S-phase and may be one of the major regulators of cell proliferation by regulating CDKN1A gene expression (Koh 2009)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

binds to the proximal Sp1 binding GC box 5/6, which is a direct target of regulation by Sp1 and Sp family members (increases Sp1 binding to the proximal promoter region, which may explain transcription activation on the short proximal promoter) (Koh 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       with MYC in in B-cell lymphomas t(8;9)(q24;p13)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS