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FLASH GENE
Symbol ZBTB5 contributors: mct/npt - updated : 04-11-2009
HGNC name zinc finger and BTB domain containing 5
HGNC id 23836
Location 9p13.2      Physical location : 37.438.101 - 37.465.407
Synonym name cDNA sequence, expressed in brain, >100kDa, related to murine Z13 protein
Synonym symbol(s) KIAA0354
DNA
TYPE functioning gene
STRUCTURE 27.30 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 4654 74.15 677 - Gerhard (2004)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine   
Lymphoid/Immunetonsils   highly
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BTB/POZ domain
  • two C2H2-type zinc fingers
    • HOMOLOGY
    interspecies ortholog to murine Zbtb5
    Homologene
    FAMILY
  • kruppel family of C2H2-type zinc-finger proteins
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text localized to the nucleus, particularly nuclear speckles (Koh 2009)
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • may be an important transcription regulator of CDKN1A and may play a critical role in regulating important biological processes controlled by CDKN1A (Koh 2009)
  • recriuting corepressor-HDACs to deacetylate the histones of nearby nucleosomes around the proximal promoter (Koh 2009)
  • potently stimulates cell growth and increases the number of cells in S-phase and may be one of the major regulators of cell proliferation by regulating CDKN1A gene expression (Koh 2009)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein binds to the proximal Sp1 binding GC box 5/6, which is a direct target of regulation by Sp1 and Sp family members (increases Sp1 binding to the proximal promoter region, which may explain transcription activation on the short proximal promoter) (Koh 2009)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with MYC in in B-cell lymphomas t(8;9)(q24;p13)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS