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FLASH GENE
Symbol TECPR2 contributors: npt/shn - updated : 12-12-2012
HGNC name tectonin beta-propeller repeat containing 2
HGNC id 19957
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six TECPR domains
  • three tryptophan-aspartic-acid dipeptide
  • a polylysin tract
    • HOMOLOGY
    interspecies ortholog to Tecpr2, Mus musculus
    ortholog to Tecpr2, Rattus norvegicus
    ortholog to tecpr2, Danio rerio
    ortholog to TECPR2, Pan troglodytes
    Homologene
    FAMILY
  • WD repeat KIAA0329 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION a positive regulator of autophagosome accumulation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text autophagy
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein six human Atg8 homologs, including the MAP1LC3 group (LC3)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG49
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • expression of SQSTM1 (p62) and MAP1LC3B (LC3) were decreased after TECPR2 siRNA knockdown leading to aberrant autophagy