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FLASH GENE

Symbol

TECPR2

contributors: npt/shn - updated : 12-12-2012

HGNC name	tectonin beta-propeller repeat containing 2
HGNC id	19957

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014844 20 splicing 8703 NP_055659 - 1411 - - NM_001172631 17 splicing 4427 NP_001166102 - 1267 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six TECPR domains
	three tryptophan-aspartic-acid dipeptide
	a polylysin tract

HOMOLOGY

interspecies	ortholog to Tecpr2, Mus musculus
	ortholog to Tecpr2, Rattus norvegicus
	ortholog to tecpr2, Danio rerio
	ortholog to TECPR2, Pan troglodytes

Homologene

FAMILY

WD repeat KIAA0329 family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION

basic FUNCTION

a positive regulator of autophagosome accumulation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text

autophagy

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

six human Atg8 homologs, including the MAP1LC3 group (LC3)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SPG49

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

expression of SQSTM1 (p62) and MAP1LC3B (LC3) were decreased after TECPR2 siRNA knockdown leading to aberrant autophagy