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FLASH GENE
Symbol TECPR2 contributors: npt/shn - updated : 12-12-2012
HGNC name tectonin beta-propeller repeat containing 2
HGNC id 19957
Corresponding disease
SPG49 Hereditary Spastic Paraparesis Type 49
Location 14q32-.31      Physical location : 102.829.299 - 102.968.817
Synonym name
  • tectonin beta-propeller repeat-containing protein 2
    • Synonym symbol(s) KIAA0329
    DNA
    TYPE functioning gene
    STRUCTURE 139.52 kb     19 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map cen -D14S985 - D14S1051 - TECPR2 - D14S272 - D14S293 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 8703 - 1411 - -
    17 splicing 4427 - 1267 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six TECPR domains
  • three tryptophan-aspartic-acid dipeptide
  • a polylysin tract
    • HOMOLOGY
    interspecies ortholog to Tecpr2, Mus musculus
    ortholog to Tecpr2, Rattus norvegicus
    ortholog to tecpr2, Danio rerio
    ortholog to TECPR2, Pan troglodytes
    Homologene
    FAMILY
  • WD repeat KIAA0329 family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION a positive regulator of autophagosome accumulation
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text autophagy
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein six human Atg8 homologs, including the MAP1LC3 group (LC3)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG49
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • expression of SQSTM1 (p62) and MAP1LC3B (LC3) were decreased after TECPR2 siRNA knockdown leading to aberrant autophagy