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FLASH GENE
Symbol AKAP6 contributors: mct - updated : 21-11-2018
HGNC name a kinase (PRKA) anchor protein 6
HGNC id 376
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two spectrin repeats
  • a C-terminal RII-alpha binding site
    • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    interspecies homolog to rattus Akap6 (80 pc)
    homolog to murine Akap6 (81.5 pc)
    Homologene
    FAMILY
    CATEGORY adaptor , chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text sarcoplasmic reticulum
    basic FUNCTION
  • a kinase (PRKA regulatory subunit RIIA), anchor protein tethering the enzyme near its physiological substrate
  • AKAP6 is an important regulator of myoblast differentiation, myotube formation, and muscle regeneration
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • anchoring/targeting type II regulatory subunits of protein kinase A to the nuclear membrane or sarcoplasmic reticulum
  • may act as an adapter for assembling multiprotein complexes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with type II regulatory subunits of protein kinase A (RII subunit of PKA)
  • interacting with phosphatase 2B (calcineurin)
  • interacting with AKAP79
  • AKAP6 promotes MYOG expression through myocyte enhancer factor 2A (MEF2A)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL14QP
    Susceptibility
    Variant & Polymorphism
    Candidate gene cardiac abnormalities
    Marker
    Therapy target
    ANIMAL & CELL MODELS