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FLASH GENE
Symbol AKAP6 contributors: mct - updated : 21-11-2018
HGNC name a kinase (PRKA) anchor protein 6
HGNC id 376
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivepharynx   moderately
Endocrinethyroid   highly
Nervousbrain   highly
 nerve   predominantly
Reproductivemale systemtestis  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac highly
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two spectrin repeats
  • a C-terminal RII-alpha binding site
    • secondary structure an amphipathic helix binding domain
    HOMOLOGY
    interspecies homolog to rattus Akap6 (80 pc)
    homolog to murine Akap6 (81.5 pc)
    Homologene
    FAMILY
    CATEGORY adaptor , chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    intracellular,nuclear envelope
    text sarcoplasmic reticulum
    basic FUNCTION
  • a kinase (PRKA regulatory subunit RIIA), anchor protein tethering the enzyme near its physiological substrate
  • AKAP6 is an important regulator of myoblast differentiation, myotube formation, and muscle regeneration
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • anchoring/targeting type II regulatory subunits of protein kinase A to the nuclear membrane or sarcoplasmic reticulum
  • may act as an adapter for assembling multiprotein complexes
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with type II regulatory subunits of protein kinase A (RII subunit of PKA)
  • interacting with phosphatase 2B (calcineurin)
  • interacting with AKAP79
  • AKAP6 promotes MYOG expression through myocyte enhancer factor 2A (MEF2A)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL14QP
    Susceptibility
    Variant & Polymorphism
    Candidate gene cardiac abnormalities
    Marker
    Therapy target
    ANIMAL & CELL MODELS