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FLASH GENE

Symbol

COL16A1

contributors: npt/mct - updated : 03/12/2008

HGNC name	collagen, type XVI, alpha 1
HGNC id	2193

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal thrombospondin domain
	fibril associated collagen with interrupted helices (FACIT)
	a several collagenous domains and a laminin G domain
	10 collagenous (Col) domains separated by 11 non-collagenous (NC) regions
	an integrin alpha1 beta1 recognition site in its C-terminal domains

conjugated

GlycoP

mono polymer

homomer , trimer

HOMOLOGY

Homologene

FAMILY	collagen family
	fibril-associated collagens with interrupted helices (FACIT) family

CATEGORY

adhesion , structural protein

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix

basic FUNCTION	involved in the integrity of the extracellular matrix
	integrated tissue-dependently into distinct fibrillar aggregates, such as D-banded cartilage fibrils and fibrillin-1-containing microfibrils
	having functions other than mere matrix receptor interactions, perhaps including regulatory functions of the proteolytic 180 and 130 kDa fragments

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	maintenance of the extracellular matrix

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to COLAI, COLAII

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glioma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS