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FLASH GENE

Symbol

DOCK3

contributors: mct - updated : 29-10-2013

HGNC name	dedicator of cytokinesis 3
HGNC id	2989

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain hindbrain cerebellum       brain forebrain cerebral cortex   highly   brain diencephalon hypothalamus   highly   brain hindbrain medulla oblongata     Reproductive male system testis         male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N terminal SH3 domain

HOMOLOGY

interspecies	homolog to C.elegans ced-5
	homolog to Drosophila CG11754

intraspecies

homolog to DOCK2

Homologene

FAMILY

DOCK family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	redistributed from cytoplasm to membranes in the presence of PS

basic FUNCTION	having a regulatory role in tau phosphorylation and in the genesis of neurofibrillary tangles
	playing a major role in APP metabolism
	novel inhibitor of Wnt/beta-catenin signaling, acting to reduce the levels of nuclear beta-catenin, increasing the levels of membrane-bound beta-catenin, and enhancing cell-cell adhesion
	with ARHGAP22, NEDD9, WASF2, are key molecules regulating RAC1 and RHO signaling that determine the mode of movement driving melanoma cell metastasis
	key molecule of the AD (Alzheimer disease)-relevant neuronal death signals that links the PSEN1-mediated death signal with the APP-mediated death signal at a point between RAC1 [or CDC42 and ASK1
	causes cellular morphological changes by activating the small GTPase RAC1
	plays likely important roles downstream of BDNF signaling in the CNS, where it regulates cell polarity and promotes axonal outgrowth by stimulating dual pathways: actin polymerization and microtubule assembly

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

other

signaling

APP metabolism

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to PS1 and PS2
	binds to and inactivates GSK3B at the plasma membrane, thereby increasing the nonphosphorylated active form of collapsin response mediator protein-2 (DPYSL2), which promotes axon branching and microtubule assembly
	DOCK3, a guanine nucleotide exchange factor, binds to the GRIN2D C-terminal domain and reduces the surface expression of GRIN2D, thereby protecting retinal ganglion cells (RGCs) from excitotoxicity

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer GRIN2D and DOCK3 might be potential therapeutic targets for treating neurodegenerative diseases such as Alzheimer disease neurosensorial visual anterior chamber GRIN2D and DOCK3 might be potential therapeutic targets for treating normal tension glaucoma

ANIMAL & CELL MODELS