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FLASH GENE
Symbol ARHGEF10 contributors: mct/npt - updated : 06-09-2017
HGNC name Rho guanine nucleotide exchange factor (GEF) 10
HGNC id 14103
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tandem DBL homology-pleckstrin homology
  • putative transmembrane domains
  • a putative WD40-like domain
    • HOMOLOGY
    intraspecies homolog to ABR protein 2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating guanine nucleotide exchange for Rac and Rho
  • third member of a Rho-specific GEF family with unusual protein architecture (Mohl 2006)
  • specifically activated RHOA, which has an important role in various process of atherosclerosis (Matsushita 2010)
  • specifically activated RhoA and might contribute to the development of atherothrombotic stroke through the regulation of RhoA–Rho kinase activity (Matsushita 2010)
  • with ARHGEF10, ARHGEF2, ARHGEF12, PLEKHG1 and ARHGEF28, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinesin-like motor protein KIF3B is a binding partner of ARHGEF10 (kinesin-like motor protein KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10)(Aoki 2009)
  • RhoA is a substrate for ARHGEF10 (novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle) (Aoki 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ischemic stroke
    Variant & Polymorphism SNP rs4376531 CC or CG increase the incidence of ischemic stroke (Matsushita 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS