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FLASH GENE

Symbol

ARHGEF10

contributors: mct/npt - updated : 06-09-2017

HGNC name	Rho guanine nucleotide exchange factor (GEF) 10
HGNC id	14103

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014629 29 - 5595 NP_055444 - 1344 - Aoki (2009)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	tandem DBL homology-pleckstrin homology
	putative transmembrane domains
	a putative WD40-like domain

HOMOLOGY

intraspecies

homolog to ABR protein 2

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	stimulating guanine nucleotide exchange for Rac and Rho
	third member of a Rho-specific GEF family with unusual protein architecture (Mohl 2006)
	specifically activated RHOA, which has an important role in various process of atherosclerosis (Matsushita 2010)
	specifically activated RhoA and might contribute to the development of atherothrombotic stroke through the regulation of RhoA–Rho kinase activity (Matsushita 2010)
	with ARHGEF10, ARHGEF2, ARHGEF12, PLEKHG1 and ARHGEF28, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	kinesin-like motor protein KIF3B is a binding partner of ARHGEF10 (kinesin-like motor protein KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10)(Aoki 2009)
	RhoA is a substrate for ARHGEF10 (novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle) (Aoki 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to ischemic stroke

Variant & Polymorphism SNP	rs4376531 CC or CG increase the incidence of ischemic stroke (Matsushita 2010)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS