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FLASH GENE
Symbol ARHGEF10 contributors: mct/npt - updated : 06-09-2017
HGNC name Rho guanine nucleotide exchange factor (GEF) 10
HGNC id 14103
Location 8p23.3      Physical location : 1.772.148 - 1.906.806
Synonym name
  • cDNA sequence, expressed in brain,>100kDa, related to ABR protein 2
  • similar to GTPase-activating protein ABR
    • Synonym symbol(s) KIAA0294, GEF10, DKFZp686H0726, MGC131664
    DNA
    TYPE functioning gene
    STRUCTURE 134.66 kb     29 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D19S1690 - D19S206 - ARHGEF10 - D19S264 - D19S1981 - cen
    Authors STS Map
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 5595 - 1344 - Aoki (2009)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tandem DBL homology-pleckstrin homology
  • putative transmembrane domains
  • a putative WD40-like domain
    • HOMOLOGY
    intraspecies homolog to ABR protein 2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating guanine nucleotide exchange for Rac and Rho
  • third member of a Rho-specific GEF family with unusual protein architecture (Mohl 2006)
  • specifically activated RHOA, which has an important role in various process of atherosclerosis (Matsushita 2010)
  • specifically activated RhoA and might contribute to the development of atherothrombotic stroke through the regulation of RhoA–Rho kinase activity (Matsushita 2010)
  • with ARHGEF10, ARHGEF2, ARHGEF12, PLEKHG1 and ARHGEF28, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinesin-like motor protein KIF3B is a binding partner of ARHGEF10 (kinesin-like motor protein KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10)(Aoki 2009)
  • RhoA is a substrate for ARHGEF10 (novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle) (Aoki 2009)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ischemic stroke
    Variant & Polymorphism SNP rs4376531 CC or CG increase the incidence of ischemic stroke (Matsushita 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS