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FLASH GENE
Symbol ARHGEF10 contributors: mct/npt - updated : 06-09-2017
HGNC name Rho guanine nucleotide exchange factor (GEF) 10
HGNC id 14103
Location 8p23.3      Physical location : 1.772.148 - 1.906.806
Synonym name
  • cDNA sequence, expressed in brain,>100kDa, related to ABR protein 2
  • similar to GTPase-activating protein ABR
  • Synonym symbol(s) KIAA0294, GEF10, DKFZp686H0726, MGC131664
    DNA
    TYPE functioning gene
    STRUCTURE 134.66 kb     29 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D19S1690 - D19S206 - ARHGEF10 - D19S264 - D19S1981 - cen
    Authors STS Map
    Physical map
    LOC392167 8 similar to Olfactory receptor 4F3 LOC389606 8 similar to bA476I15.3 (novel protein similar to septin) LOC389700 8 similar to bA110H4.2 (similar to membrane protein) LOC392168 8 hypothetical gene supported by AK127000 LOC153561 8 hypothetical protein LOC153561 LOC169270 8p23.3 hypothetical protein LOC169270 LOC392278 8 similar to Rab coupling protein; Rab-interacting recycling protein; Rab effector protein; rab11-family interacting protein 1 FBXO25 8p23.3 F-box only protein 25 LOC392169 8 LOC392169 INM01 8p23.3 hypothetical protein INM01 LOC389607 8 hypothetical gene supported by AK128318 LOC157697 8p23.3 hypothetical protein LOC157697 LOC392170 8 similar to hypothetical protein P1295.15 LOC346910 8p23.3 similar to putative nuclear protein (4B256) LOC392171 8 similar to ENSANGP00000017949 LOC392172 8 similar to hypothetical protein LOC392173 8 similar to Proline-rich protein MP-2 precursor LOC389608 8 LOC389608 LOC392174 8 similar to stage-specific S antigen homolog DLGAP2 8p23 discs, large (Drosophila) homolog-associated protein 2 CLN8 8p23.3 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) LOC286088 8p23.3 similar to TBP-associated factor 15 isoform 1; TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kD; TATA box-binding protein-associated factor 2N (RNA-binding protein 56); TATA box binding protein (TBP)- ARHGEF10 8p23 Rho guanine nucleotide exchange factor (GEF) 10 KIAA0711 8p23.3 Homo sapiens KIAA0711 gene product (KIAA0711), mRNA. LOC392175 8 similar to high molecular weight glutenin subunit x MYOM2 8p23.3 myomesin (M-protein) 2, 165kDa LOC392176 8 similar to proteoglycan core protein, cartilage - bovine (fragments) LOC392177 8 LOC392177 LOC389609 8 hypothetical gene supported by AK128880 CSMD1 8p23.2 CUB and Sushi multiple domains 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    29 - 5595 - 1344 - Aoki (2009)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tandem DBL homology-pleckstrin homology
  • putative transmembrane domains
  • a putative WD40-like domain
  • HOMOLOGY
    intraspecies homolog to ABR protein 2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • stimulating guanine nucleotide exchange for Rac and Rho
  • third member of a Rho-specific GEF family with unusual protein architecture (Mohl 2006)
  • specifically activated RHOA, which has an important role in various process of atherosclerosis (Matsushita 2010)
  • specifically activated RhoA and might contribute to the development of atherothrombotic stroke through the regulation of RhoA–Rho kinase activity (Matsushita 2010)
  • with ARHGEF10, ARHGEF2, ARHGEF12, PLEKHG1 and ARHGEF28, are involved in cyclic-stretch-induced perpendicular reorientation of endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • kinesin-like motor protein KIF3B is a binding partner of ARHGEF10 (kinesin-like motor protein KIF3B may modulate the ARHGEF10-RhoA pathway through the binding to ARHGEF10)(Aoki 2009)
  • RhoA is a substrate for ARHGEF10 (novel RhoA-dependent signaling pathway under the control of ARHGEF10 has a pivotal role in the regulation of the cell division cycle) (Aoki 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ischemic stroke
    Variant & Polymorphism SNP rs4376531 CC or CG increase the incidence of ischemic stroke (Matsushita 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS