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FLASH GENE
Symbol BID contributors: mct/pgu - updated : 18-09-2015
HGNC name BH3 interacting domain death agonist
HGNC id 1050
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       loss of function
loss of BID function impaired the ability of NOD2 but not TLR3 to trigger tissue repair responses upon injury
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
cancerreproductivebreast
with its substrate CTSB were shown to be molecular links between apoptosis and autophagy in breast cancer MCF-7 cells exposed to the cytostatic drug, camptothecin
ANIMAL & CELL MODELS
  • Bid-/- mice are unresponsive to local or systemic exposure to NOD agonists or their protective effect in experimental colitis