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FLASH GENE

Symbol

KCNK3

contributors: npt/mct - updated : 28-02-2017

HGNC name	potassium channel, subfamily K, member 3
HGNC id	6278

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PPH4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low loss of function in pulmonary artery smooth muscle cells and endothelial cell

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular rythm   promising drug targets against atrial fibrillation, the most common arrhythmia in the elderly

ANIMAL & CELL MODELS

	disruption of the TASK1 gene in mice resulted in an autonomous aldosterone production and caused a remarkable aberrant expression of aldosterone synthase in zona fasciculata cells that normally produce glucocorticoids
	Task1-null mice, compared with their controls, became overweight, mainly because of an increase in white adipose tissue mass and BAT whitening