| basic FUNCTION
| potassium non voltage-gated heat activated background channel outwardly rectifying |
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acting as an outward rectifier when external potassium concentration is low; when external potassium concentration is high, current is inward |
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playing an important role in mediating pulmonary vascular responses to changes in extracellular pH, and in the regulation of pulmonary vascular tone |
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play a key role in modulating effector functions of T lymphocytes |
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may serve as molecular sensors for central chemoreception because they are highly expressed in multiple neuronal populations in the respiratory pathway and contribute to their pH sensitivity  |
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controls the resting membrane potential in humanpulmonary artery smooth muscle cells (PASMCs), and renders these cells sensitive to a variety of vasoactive factors |
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regulate neuronal firing and may contribute to the specialized responses of orexin neurons to glucose and pH |
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role in enhancing neuronal excitability and promoting high-frequency firing, but KCNK3/KCNK9 subunits are not essential for orexin cell responses to glucose and pH |
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plays a functional role in the repolarization of the cardiac action potential and contributes to the maintenance of heart rate variability (HRV) |
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is vital for setting the resting membrane potential and is the primary target for volatile anesthetics |
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plays a major role in a number of physiological functions throughout the CNS and periphery, and mechanisms that alter KCNK3 function and availability are likely to have a significant systemic impact |
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role potential for KCNK3 to uniquely contribute to synaptic plasticity |
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acid-sensitive KCNK1, KCNK3, KCNK9 change ion selectivity and become permeable to sodium in extracellular acidification |
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K(+) leak channel that mediates hypoxic depolarisation in neurons |
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oligodendrocytes express functional KCNK3 channels which contribute to oligodendrocyte damage in hypoxia |
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is an important modulator of membrane voltage and Ca(2+) entry |
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important role for KCNK3 channels in limiting pancreatic alpha-cell excitability and glucagon secretion during glucose stimulation |
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controls the thermogenic activity in brown adipocytes through modulation of ADRB signaling |
