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FLASH GENE
Symbol FGR contributors: - updated : 20-07-2006
HGNC name Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
HGNC id 3697
Location 1p36.2-p36.1      Physical location : 27.938.802 - 27.961.727
Synonym name
  • c-SRC-2 protein
  • p55-c-FGR protein
  • Synonym symbol(s) SRC2, FLJ43153, c-fgr, p55c-fgr
    EC.number 2.7.1.112
    DNA
    TYPE functioning gene
    STRUCTURE 11.00 kb     11 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Physical map
    SMARCF1 1p36.1-p35 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 FLJ20477 1p35.3 hypothetical protein FLJ20477 ZDHHC18 1p35.3 zinc finger, DHHC domain containing 18 SFN 1p35.3 stratifin FLJ10349 1p35.3 hypothetical protein FLJ10349 FLJ12455 1p35.3-p35.1 hypothetical protein FLJ12455 NR0B2 1p36.1 nuclear receptor subfamily 0, group B, member 2 NUDC 1p35-p34 nuclear distribution gene C homolog (A. nidulans) FLJ34633 1p35.3 hypothetical protein FLJ34633 LOC391022 1 similar to DC2 protein LOC388610 1 LOC388610 MGC16491 1p35.3 hypothetical protein MGC16491 SLC9A1 1p35 solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) LOC391023 1 similar to ribosomal protein L18a; 60S ribosomal protein L18a LOC284609 1p35.3 similar to hypothetical protein FLJ20420 LOC148356 1p35.3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 WDTC1 1p35.3 WD and tetratricopeptide repeats 1 DKFZP564D0478 1p35.3 hypothetical protein DKFZp564D0478 JFC1 1p35.3 hypothetical protein DKFZp564D0478 MAP3K6 1p35.2 mitogen-activated protein kinase kinase kinase 6 FCN3 1p36-p32 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) LOC388611 1 similar to EAPG6122 GPR3 1p35.1-p34.3 G protein-coupled receptor 3 WASF2 1p36.11-p34.3 WAS protein family, member 2 DJ159A19.3 1p36.13 hypothetical protein DJ159A19.3 LOC388612 1 LOC388612 FGR 1p35 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog G1P3 1p35 interferon, alpha-inducible protein (clone IFI-6-16) LOC339409 1p35.3 similar to Procollagen (type III) N-endopeptidase MGC34648 1p35.3 hypothetical protein MGC34648 STX12 1p35-p34.1 syntaxin 12 PPP1R8 1p35 protein phosphatase 1, regulatory (inhibitor) subunit 8 C1orf38 1p35.2 chromosome 1 open reading frame 38 RPA2 1p35 replication protein A2, 32kDa ASML3B 1p35.2 acid sphingomyelinase-like phosphodiesterase FLJ10307 1p35.2 hypothetical protein FLJ10307 EYA3 1p36 eyes absent homolog 3 (Drosophila) LOC388613 1 similar to Microsomal signal peptidase 25 kDa subunit (SPase 25 kDa subunit) (SPC25) LOC391024 1 similar to RIKEN cDNA 2610313E07 PTAFR 1p35.1-p34.3 platelet-activating factor receptor DNAJC8 1p35.3 DnaJ (Hsp40) homolog, subfamily C, member 8 ATPIF1 1p35.3 ATPase inhibitory factor 1 SESN2 1p35.3 sestrin 2 FLJ20045 1p35.2 TRAP/mediator complex subunit p28b
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion lymph highly
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • a SH2 domain
  • a SH3 domain
  • HOMOLOGY
    interspecies homolog to feline Gardner-Rasheed sarcoma viral (c-fgr) oncogene
    Homologene
    FAMILY SRC family (signal transduction)
    CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION
    basic FUNCTION target for beta 2 integrin-induced c-CBL-mediated ubiquitination in adherent neutrophils
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binds PTPNS1
    cell & other i5 membrane associated
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS