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FLASH GENE
Symbol KLF10 contributors: mct - updated : 18-01-2016
HGNC name Kruppel-like factor 10
HGNC id 11810
Location 8q22.3      Physical location : 103.661.004 - 103.667.983
Synonym name
  • early growth response 2, alpha
  • TGFB inducible early growth response
  • EGR-alpha
  • transforming growth factor-beta-inducible early growth response protein 1
  • Synonym symbol(s) EGRA, TIEG, TIEG1
    DNA
    TYPE functioning gene
    STRUCTURE 6.98 kb     4 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 initiation site 3249 51.2 469 low, if any Fautsch, Ivanov (2008)
  • isoform b
  • 4 - 2968 52.4 480 - Fautsch, Ivanov (2008)
  • isoform a
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     mouth   highly
    Lymphoid/Immunelymph node   highly
    Nervousnerve   highly
    Reproductivefemale systemovary   
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Muscularstriatumskeletal highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text highly, in osteoblasts and a variety of tissues and muscle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three C terminus Sp1-like zinc finger motifs with EGRA produced from an alternate promoter
  • a highly conserved 81 AA DNA binding domain
  • three C2H2-type zinc fingers
  • conjugated Other
    HOMOLOGY
    interspecies homolog to murine Klf10 (85.6pc)
    homolog to rattus Klf10 (85.0pc)
    Homologene
    FAMILY
  • sp1 C2H2-type zinc-finger protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • transcriptional repressor involved in the regulation of cell growth
  • inhibiting cell growth and binding to the consensus sequence 5'-ggtgtg-3'
  • inducing and promoting apoptosis through the mitochondrial apoptotic pathway
  • inhibiting Smad7 expression in bronchial epithelial cells
  • may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers
  • play a major role in the TGFbeta inhibition of cell proliferation and inflammation and induction of apoptosis, and its overexpression in human osteoblasts and pancreatic carcinoma cells mimics the actions of TGFbeta
  • required circadian transcriptional regulator that links the molecular clock to energy metabolism in the liver
  • may be a feedback regulator of myostatin and TGF-beta that prevents excess action in myoblasts (Miyake 2010)
  • involved in bone metabolism and exerts antiproliferative activity
  • KLF10 and JARID1B may cooperate to suppress tumorigenesis by enhancing TGFB signaling
  • KLF10 and JARID1B cooperate in repressing SMAD7 transcription and thereby antagonize skin cancer development
  • negative regulator of the myoblast pool that causes inhibition of myotube formation during myogenic differentiation
  • induced in response to estrogen, and directly modulates the transcription of TMBIM1
  • induces cell apoptosis through modulation of BI-1 expression and Ca2+ homeostasis in estrogen-responding adenocarcinoma cells
  • important role in regulating tenocytes adhesion, spreading, and proliferation throughout the aging process
  • importance of KLF10 and NPPA/NPR1 in exerting influences on chronic pulmonary disease pathogenesis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA DNA-binding protein
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • regulating ITGAD
  • target of VHL
  • interacts with JARID1B (the repression domains of KLF10 bind to the C-terminus of JARID1B)
  • is a transcription factor that regulates the expression of IL12B in bone marrow-derived macrophages (M-BMMs)
  • TGFB2 regulates hypothalamic TRH expression through the TGFbeta inducible early gene-1 (KLF10) during fetal development
  • CDK2 phosphorylation regulates the protein stability of KLF10 by interfering with binding of the E3 ligase SIAH1
  • KLF10 acts as a transcriptional repressor of NPR1
  • cell & other
    REGULATION
    induced by TGF-beta and MSTN
    Other ubiquitinated, mediated by SIAH1 and leading to its subsequent proteasomal degradation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in renal clear cell carcinoma and other tumors
    tumoral     --low  
    in melanomas
    tumoral     --low  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Klf10-deficient mice were more sensitive to lipopolysaccharide or ovalbumin challenge and showed more severe inflammatory histological changes in the lungs