basic FUNCTION
| transcriptional repressor involved in the regulation of cell growth |
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inhibiting cell growth and binding to the consensus sequence 5'-ggtgtg-3' |
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inducing and promoting apoptosis through the mitochondrial apoptotic pathway |
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inhibiting Smad7 expression in bronchial epithelial cells |
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may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers |
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play a major role in the TGFbeta inhibition of cell proliferation and inflammation and induction of apoptosis, and its overexpression in human osteoblasts and pancreatic carcinoma cells mimics the actions of TGFbeta |
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required circadian transcriptional regulator that links the molecular clock to energy metabolism in the liver |
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may be a feedback regulator of myostatin and TGF-beta that prevents excess action in myoblasts (Miyake 2010) |
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involved in bone metabolism and exerts antiproliferative activity |
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KLF10 and JARID1B may cooperate to suppress tumorigenesis by enhancing TGFB signaling |
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KLF10 and JARID1B cooperate in repressing SMAD7 transcription and thereby antagonize skin cancer development |
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negative regulator of the myoblast pool that causes inhibition of myotube formation during myogenic differentiation |
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induced in response to estrogen, and directly modulates the transcription of TMBIM1 |
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induces cell apoptosis through modulation of BI-1 expression and Ca2+ homeostasis in estrogen-responding adenocarcinoma cells |
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important role in regulating tenocytes adhesion, spreading, and proliferation throughout the aging process |
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importance of KLF10 and NPPA/NPR1 in exerting influences on chronic pulmonary disease pathogenesis |