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FLASH GENE
Symbol SEMA3C contributors: mct/npt - updated : 30-10-2017
HGNC name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
HGNC id 10725
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal peptide
  • the SEMA domain containing about 14 cysteine residues with a RGD domain
  • an Ig-like motif
  • a psi domain
  • a C terminal short basic domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • semaphorin family
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text secreted
    basic FUNCTION
  • may be involved in diverse cell survival mechanisms
  • repellent of the nerve growth cone guidance
  • may help to establish the dopaminergic projection from the midbrain to the striatum during embryonic development (Hernández-Montiel 2008)
  • had an attractive effect and enhanced axon growth (Hernández-Montiel 2008)
  • neurovascular guiding molecule, regulated directly by GATA6 (Kodo 2009)
  • promoting the migration of breast cancer cells after activation by ADAMTS1 (Esselens 2010)
  • is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins
  • SEMA3C constitutes an adipocyte-derived paracrine signal that influences extracellular matrix (ECM) composition and may play a pathophysiological role in white adipose tissue (WAT)
  • SEMA3A, -3C, and -3F, likely with coreceptors NRP1, NRP2, and plexin-A1 and/or -A3, promote migration and possibly other activities of human DCs during innate and adaptive immune responses
  • promotes epithelial-to-mesenchymal transition (EMT) and stem-like phenotypes in prostate cells
  • SEMA3C promotes migration, invasion and cell dissemination
  • SEMA3C is a secreted semaphorin that plays an important role in the maintenance of cancer stem-like cells, promotes migration and invasion, and may facilitate angiogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    SEMA32C/SEMA3D signaling is an evolutionarily conserved regulator of enteric nervous system (ENS) development whose dys-regulation is a cause of enteric aganglionosis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GATA6 (SEMA3C and PLXNA2 are directly regulated by GATA6 through consensus binding sites on their enhancer elements and GATA6 mutations disturbs semaphorin-plexin signaling to varying degrees, resulting in abnormal development of the cardiac outflow tract)(Kodo 2009)
  • ligand of receptor plexin A2 (PLXNA2)(Kodo 2009)
  • motoneuronal SEMA3C regulates the shared SEMA3 neuropilin receptors NRP1 and NRP2 levels in opposite ways at the growth cone surface
  • axonal guidance cue SEMA3C promotes normal alveolar growth
  • neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation
  • FOXA1 is a negative regulator of SEMA3C and SEMA3C is a novel target of AR, GATA2, and FOXA1
  • SEMA3C drives activation of multiple RTKs including EGFR, ERBB2, and MET in a cognate ligand-independent manner via PLXNB1
    • cell & other
    REGULATION
    activated by cleavage by ADAMTS1, and thus contributing to the metastatic program (Esselens 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the synovial tissue of rheumatoid arthritis and osteoarthritis
    tumoral     --other  
    aberrant expression of SEMA3C is correlated with poor prognosis of pancreatic ductal adenocarcinoma (PDAC) patients and promotes tumor growth and metastasis by activating ERK1/2 signaling pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS