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FLASH GENE

Symbol

GSTP1

contributors: mct/npt/pgu/shn - updated : 03-10-2014

HGNC name	glutathione S-transferase pi 1
HGNC id	4638

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         in prostate cancer by methylation of promoter constitutional     --low   in placentas of preeclampsia and HELLP syndrome tumoral     --low   in tissues of esophageal carcinomas compared to adjacent normal tissues and residual benign tissues

Susceptibility

susceptibility factor in squamous-cell carcinoma of the esophagus and in Barrett's esophagus carcinoma to chronic obstructive pulmonary disease to lung cancer to childhood asthma to type-2 diabetes

Variant & Polymorphism SNP	increasing the risk of chronic obstructive pulmonary disease
	chemotherapy induced leukemia
	Ile105Val polymorphism in the GSTP1 gene and childhood asthma is significantly associated in childhood asthma, modified by GSTM1
	GSTP1 exon 5 polymorphism, associated with risk of lung cancer in smokers

Candidate gene	for sensitive detection in plasma or serum of cancer gastric and prostatic, using DNA methylation markers
	for macular telangiectasia type 2
	methylation of the promoter is a common molecular alteration in prostate cancer that may be a useful adjunct to serum screening tests and digital rectal examination findings
Marker	strong associations between APC, GSTP1 and SOCS1 gene promoter methylation and the risk of HCC, suggesting these to be promising biomarkers for hepatocellular carcinoma (HCC)
Therapy target	intraperitoneally administation of GSTP1 in mouse models of endotoxin shock significantly decreased mortality of endotoxic shock and inhibited acute lung injury and peritonitis

ANIMAL & CELL MODELS