Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GSTP1 contributors: mct/npt/pgu/shn - updated : 03-10-2014
HGNC name glutathione S-transferase pi 1
HGNC id 4638
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • region 195-208 is critical for nuclear translocation, which is mediated by a novel and non-classical nuclear localization signal, and in some cancer cells, the nuclear expression of GSTP1 appears to correlate with resistance to anti-cancer drugs
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to Gstp1, Mus musculus
    ortholog to Gstp1, Rattus norvegicus
    ortholog to gstp1, Danio rerio
    ortholog to GSTP1, Pan troglodytes
    Homologene
    FAMILY
  • GST superfamily
  • Pi family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • catalizing the conjugation of many hydrophobic and electronic compounds with reduced glutathione
  • acting as a zeaxanthin-binding protein in the macula of the eye
  • playing an important role in detoxification and the metabolism of xenobiotics
  • regulates the MAPK1-MAPK7 signaling pathway
  • plays a key role in cellular protection against oxidative stress
  • involved in multiple cellular functions, including phase II metabolism, stress response, signaling, and apoptosis
  • major phase II xenobiotic-metabolizing enzyme in the lung
  • mportant detoxification enzyme, has been shown to modulate the activity of JNKs by inhibiting apoptosis and by causing cell proliferation and tumor growth
  • a Cdk5 regulatory protein and a critical determinant of Cdk5 activity in human Alzheimer's disease brains and various cancer and neuronal cells
  • confers a high degree of neuroprotection under neurotoxic conditions
  • involved in the protection of cellular components against electrophilic compounds or oxidative stress
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism drug
    signaling
    detoxification
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • 'tissue' transglutaminase, tTG
  • JNK
  • Fanconi anemia group C protein, FANCC
  • tumor necrosis factor receptor-associated factor 2, TRAF2
  • transcriptional target of the TP53 tumor suppressor gene
  • modulates MAPK8 and MAPK9 activity through a direct interaction with JNK substrate, ATF2
  • MYCN in neuroblastoma cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    in prostate cancer by methylation of promoter
    constitutional     --low  
    in placentas of preeclampsia and HELLP syndrome
    tumoral     --low  
    in tissues of esophageal carcinomas compared to adjacent normal tissues and residual benign tissues
    Susceptibility
  • susceptibility factor in squamous-cell carcinoma of the esophagus and in Barrett's esophagus carcinoma
  • to chronic obstructive pulmonary disease
  • to lung cancer
  • to childhood asthma
  • to type-2 diabetes
  • Variant & Polymorphism SNP
  • increasing the risk of chronic obstructive pulmonary disease
  • chemotherapy induced leukemia
  • Ile105Val polymorphism in the GSTP1 gene and childhood asthma is significantly associated in childhood asthma, modified by GSTM1
  • GSTP1 exon 5 polymorphism, associated with risk of lung cancer in smokers
  • Candidate gene
  • for sensitive detection in plasma or serum of cancer gastric and prostatic, using DNA methylation markers
  • for macular telangiectasia type 2
  • methylation of the promoter is a common molecular alteration in prostate cancer that may be a useful adjunct to serum screening tests and digital rectal examination findings
  • Marker
  • strong associations between APC, GSTP1 and SOCS1 gene promoter methylation and the risk of HCC, suggesting these to be promising biomarkers for hepatocellular carcinoma (HCC)
  • Therapy target
  • intraperitoneally administation of GSTP1 in mouse models of endotoxin shock significantly decreased mortality of endotoxic shock and inhibited acute lung injury and peritonitis
  • ANIMAL & CELL MODELS