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FLASH GENE

Symbol

GSTP1

contributors: mct/npt/pgu/shn - updated : 03-10-2014

HGNC name	glutathione S-transferase pi 1
HGNC id	4638

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly Reproductive female system placenta     highly Homo sapiens Respiratory lung       highly Visual eye anterior segment cornea   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Respiratory epithelial cell Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

region 195-208 is critical for nuclear translocation, which is mediated by a novel and non-classical nuclear localization signal, and in some cancer cells, the nuclear expression of GSTP1 appears to correlate with resistance to anti-cancer drugs

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to Gstp1, Mus musculus
	ortholog to Gstp1, Rattus norvegicus
	ortholog to gstp1, Danio rerio
	ortholog to GSTP1, Pan troglodytes

Homologene

FAMILY	GST superfamily
	Pi family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	catalizing the conjugation of many hydrophobic and electronic compounds with reduced glutathione
	acting as a zeaxanthin-binding protein in the macula of the eye
	playing an important role in detoxification and the metabolism of xenobiotics
	regulates the MAPK1-MAPK7 signaling pathway
	plays a key role in cellular protection against oxidative stress
	involved in multiple cellular functions, including phase II metabolism, stress response, signaling, and apoptosis
	major phase II xenobiotic-metabolizing enzyme in the lung
	mportant detoxification enzyme, has been shown to modulate the activity of JNKs by inhibiting apoptosis and by causing cell proliferation and tumor growth
	a Cdk5 regulatory protein and a critical determinant of Cdk5 activity in human Alzheimer's disease brains and various cancer and neuronal cells
	confers a high degree of neuroprotection under neurotoxic conditions
	involved in the protection of cellular components against electrophilic compounds or oxidative stress

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

drug

signaling

detoxification

a component

INTERACTION

DNA

RNA

small molecule

protein	'tissue' transglutaminase, tTG
	JNK
	Fanconi anemia group C protein, FANCC
	tumor necrosis factor receptor-associated factor 2, TRAF2
	transcriptional target of the TP53 tumor suppressor gene
	modulates MAPK8 and MAPK9 activity through a direct interaction with JNK substrate, ATF2
	MYCN in neuroblastoma cells

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         in prostate cancer by methylation of promoter constitutional     --low   in placentas of preeclampsia and HELLP syndrome tumoral     --low   in tissues of esophageal carcinomas compared to adjacent normal tissues and residual benign tissues

Susceptibility

susceptibility factor in squamous-cell carcinoma of the esophagus and in Barrett's esophagus carcinoma to chronic obstructive pulmonary disease to lung cancer to childhood asthma to type-2 diabetes

Variant & Polymorphism SNP	increasing the risk of chronic obstructive pulmonary disease
	chemotherapy induced leukemia
	Ile105Val polymorphism in the GSTP1 gene and childhood asthma is significantly associated in childhood asthma, modified by GSTM1
	GSTP1 exon 5 polymorphism, associated with risk of lung cancer in smokers

Candidate gene	for sensitive detection in plasma or serum of cancer gastric and prostatic, using DNA methylation markers
	for macular telangiectasia type 2
	methylation of the promoter is a common molecular alteration in prostate cancer that may be a useful adjunct to serum screening tests and digital rectal examination findings
Marker	strong associations between APC, GSTP1 and SOCS1 gene promoter methylation and the risk of HCC, suggesting these to be promising biomarkers for hepatocellular carcinoma (HCC)
Therapy target	intraperitoneally administation of GSTP1 in mouse models of endotoxin shock significantly decreased mortality of endotoxic shock and inhibited acute lung injury and peritonitis

ANIMAL & CELL MODELS