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FLASH GENE

Symbol

TMEFF1

contributors: mct - updated : 06-02-2024

HGNC name	transmembrane protein with EGF-like and two follistatin-like domains 1
HGNC id	11866

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   lower levels of TMEFF1 expression in brain tumors than normal brain tissue tumoral     --over   in ovarian cancer cells induced increased cellular proliferation, migration, and invasion but reduced apoptosis tumoral     --over   of ANHAK and TMEFF1 in ovarian cancer indicated a higher degree of tumor malignancy and a worse prognosis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary may be considered as a potential therapeutic target for ovarian cancer cardiovascular cardiomyopathy   could be a therapeutic target to control the development of cardiac hypertrophy cancer reproductive ovary the interaction between AHNAK and TMEFF1 may become a potential anti-tumor target for ovarian cancer treatment

ANIMAL & CELL MODELS

	plays a protective role in the modulation of adverse cardiac remodeling from pressure overload in mice
	high Tgfb1 doses increased tomoregulin-1 (Tmeff1) levels, resulting in the repression of Bmp2 and bone formation in mice