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FLASH GENE
Symbol TMEFF1 contributors: mct - updated : 06-02-2024
HGNC name transmembrane protein with EGF-like and two follistatin-like domains 1
HGNC id 11866
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative extracellular domain
  • signal peptide
  • EGF like domains
  • a serine protease domain (Kazal type)
  • a transmembrane region
  • two potential glycosaminoglycan attachment sites
  • two follistatin-like and an epidermal growth factor-like domain, participating in nodal and bone morphogenetic protein signaling
    • HOMOLOGY
    interspecies homolog to murine Tmeff1
    Homologene
    FAMILY
  • tomoregulin family
    • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • expressed on the cell membrane
  • predominantly redistributed to the endoplasmic reticulum (ER) when coexpressed with addicsin (ARL6IP5)
    • basic FUNCTION
  • potential role for TMEFF1 in growth factor signaling (
  • may behave as a tumor suppressor gene in brain cancers
  • inhibits NODAL signaling through direct binding to the nodal coreceptor Cripto
  • having different activities depending on the presence of the cytoplasmic tail and its anchorage to the membrane
  • TMEFF1 and TMEFF2 could be playing similar roles in different tissues and/or developmental stages
  • is a growth factor that is primarily involved in embryonic development and adult central nervous system (CNS) function
  • is a carcinogenic gene in ovarian cancer and can be regulated by TP53 transcription
  • involved in the physiological functions of the central nervous system, embryonic development, and other biological processes
  • acts as a tumor-promoting gene in ovarian cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the NODAL coreceptor CRIPTO, but does not associate with either NODAL or the type I ALK (activin receptor-like kinase) 4 receptor
  • tomoregulin-1 (TMEFF1) is a novel addicsin (ARL6IP5)-associated factor
  • ARL6IP5 in the ER controls intracellular TMEFF1 trafficking from the ER to plasma membrane and regulates cell migration through its interaction with TMEFF1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    lower levels of TMEFF1 expression in brain tumors than normal brain tissue
    tumoral     --over  
    in ovarian cancer cells induced increased cellular proliferation, migration, and invasion but reduced apoptosis
    tumoral     --over  
    of ANHAK and TMEFF1 in ovarian cancer indicated a higher degree of tumor malignancy and a worse prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    may be considered as a potential therapeutic target for ovarian cancer
    cardiovascularcardiomyopathy 
    could be a therapeutic target to control the development of cardiac hypertrophy
    cancerreproductiveovary
    the interaction between AHNAK and TMEFF1 may become a potential anti-tumor target for ovarian cancer treatment
    ANIMAL & CELL MODELS
  • plays a protective role in the modulation of adverse cardiac remodeling from pressure overload in mice
  • high Tgfb1 doses increased tomoregulin-1 (Tmeff1) levels, resulting in the repression of Bmp2 and bone formation in mice