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FLASH GENE
Symbol CITED1 contributors: mct/npt - updated : 08-07-2008
HGNC name Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
HGNC id 1986
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
Reproductivemale systemtestis   
Skin/Tegumentskin    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentmelanocyte
cell lineage
cell lines pigmented melanoma cells
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nuclear protein with a serine /threonine-rich region
  • a glutamic-aspartic (ED) rich C terminal domain with transactivating activity
    • HOMOLOGY
    interspecies homolog to murine Cited1
    Homologene
    FAMILY CITED family of cofactors
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • transcriptional activator dependent on transforming growth factor beta signaling pathway and interaction with SMAD4
  • functioning as a cell cycle-dependent transcriptional cofactor whose activity is regulated by phosphorylation
  • involved in regulating a wide variety of CBP/p300-dependent transcriptional responses
    • CELLULAR PROCESS cell life
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text epidermal development and maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MADH4
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the condensed metanephric mesenchyme could play a role in Wilms tumor initiation and pathogenesis
    tumoral     --over  
    in papillary thyroid carcinoma (PTC), pigmented melanoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene marker of primitive blastema in Wilms tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS