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FLASH GENE
Symbol SP2 contributors: - updated : 07-06-2005
HGNC name Sp2 transcription factor
HGNC id 11207
Location 17q21.32      Physical location : 45.973.515 - 46.006.321
Synonym symbol(s) KIAA0048
DNA
TYPE functioning gene
STRUCTURE 32.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure binding weakly the GT box,not binding GC box
MAPPING cloned Y linked   status confirmed
regionally located linked to RARA and HOXb genes
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines several cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a long serine/threonine and glutamine rich region (transactivation domain) at the N terminus
  • a buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers
  • a DNA binding domain of three zinc fingers of the Cys2/His2 type near the C terminus
  • HOMOLOGY
    interspecies ortholog to murine Sp2
    homolog to Drosophila CG5669
    homolog to C.elegans T22C8.5
    intraspecies homolog to SP1
    Homologene
    FAMILY Sp1 family of zinc-finger transcription activators
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • regulating expression of the T-cell antigen receptor (TCR) gene
  • activating selectively mRNA synthesis from genes containing functional recognition sites
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to Gc box promoters elements
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS