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FLASH GENE

Symbol

SNCG

contributors: mct/npt/pgu - updated : 06-01-2010

HGNC name	synuclein, gamma (breast cancer-specific protein 1)
HGNC id	11141

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian carcinoma, and in breast carcinomas but not in normal epithelium tumoral     --over   in hepatocellular carcinoma, with distant metastasis and demethylation of SNCG CpG island is an early sign of genetic abnormality in liver cirrhosis preceding hepatocarcinogenesis tumoral     --over   in pancreatic cancer correlated with major invasive parameters, including perineural invasion and lymph node metastasis

Susceptibility

to neurologic disease (but not Parkinson disease)

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     may serve as a promising molecular target of early diagnosis and anticancer therapy cancer reproductive breast potential target for breast cancer treatment

ANIMAL & CELL MODELS