Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SNCG contributors: mct/npt/pgu - updated : 06-01-2010
HGNC name synuclein, gamma (breast cancer-specific protein 1)
HGNC id 11141
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six imperfect repeats of 11 aminoacids with the consensus core KTKEGV
    • HOMOLOGY
    Homologene
    FAMILY
  • neuronal protein family synuclein
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • may be involved in exocytosis of synaptic vesicles
  • may be a centrosome-associated protein
  • playing a role in neurofilament network integrity
  • regulates many pathways in growth and progression of breast cancer
  • role in promoting a more robust G protein activation of PLCB2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • able to bind directly to several transcription factors
  • competes for GNAQ association, but not for activators that bind to the N-terminus
  • binding of SNCG reduces the catalytic activity of PLCB2 by mechanism that involves inhibition of product release without affecting membrane interactions
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian carcinoma, and in breast carcinomas but not in normal epithelium
    tumoral     --over  
    in hepatocellular carcinoma, with distant metastasis and demethylation of SNCG CpG island is an early sign of genetic abnormality in liver cirrhosis preceding hepatocarcinogenesis
    tumoral     --over  
    in pancreatic cancer correlated with major invasive parameters, including perineural invasion and lymph node metastasis
    Susceptibility to neurologic disease (but not Parkinson disease)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may serve as a promising molecular target of early diagnosis and anticancer therapy
    cancerreproductivebreast
    potential target for breast cancer treatment
    ANIMAL & CELL MODELS