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FLASH GENE

Symbol

SNCG

contributors: mct/npt/pgu - updated : 06-01-2010

HGNC name	synuclein, gamma (breast cancer-specific protein 1)
HGNC id	11141

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.73 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	promoter is regulated in neuronal and glial cells

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003087 5 - 855 - 127 - Buchman (1998)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine adrenal gland       highly Nervous brain midbrain substantia nigra   highly   nerve cranial nerve     highly Visual eye retina     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory visual ganglion cell layer highly Nervous peripherous     highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous glia Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

perinatal

Text	during pre and postnatal development in the cell bodies and axons of primary sensory neurons,sympathetic neurons and motoneurons of peripheral and central nervous system

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six imperfect repeats of 11 aminoacids with the consensus core KTKEGV

HOMOLOGY

Homologene

FAMILY

neuronal protein family synuclein

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle

basic FUNCTION	may be involved in exocytosis of synaptic vesicles
	may be a centrosome-associated protein
	playing a role in neurofilament network integrity
	regulates many pathways in growth and progression of breast cancer
	role in promoting a more robust G protein activation of PLCB2

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	able to bind directly to several transcription factors
	competes for GNAQ association, but not for activators that bind to the N-terminus
	binding of SNCG reduces the catalytic activity of PLCB2 by mechanism that involves inhibition of product release without affecting membrane interactions

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian carcinoma, and in breast carcinomas but not in normal epithelium tumoral     --over   in hepatocellular carcinoma, with distant metastasis and demethylation of SNCG CpG island is an early sign of genetic abnormality in liver cirrhosis preceding hepatocarcinogenesis tumoral     --over   in pancreatic cancer correlated with major invasive parameters, including perineural invasion and lymph node metastasis

Susceptibility

to neurologic disease (but not Parkinson disease)

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     may serve as a promising molecular target of early diagnosis and anticancer therapy cancer reproductive breast potential target for breast cancer treatment

ANIMAL & CELL MODELS