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FLASH GENE
Symbol GTF2H4 contributors: mct - updated : 26-02-2015
HGNC name general transcription factor IIH, polypeptide 4, 52kDa
HGNC id 4658
Location 6p21.33      Physical location : 2.168.961 - 30.881.879
Synonym name
  • TFIIH basal transcription factor complex p52 subunit
  • basic transcription factor 2 52 kDa subunit
  • Synonym symbol(s) TF2H, TFIIH, TFB2, BTF2-p52
    DNA
    TYPE functioning gene
    STRUCTURE 5.90 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 1736 - 462 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemovary  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc finger domain
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Tfb2
    homolog to murine Gtf2h4 (98.9pc)
    homolog to rattus Gtf2h4 (99.1pc)
    Homologene
    FAMILY
  • TFB2 family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • recruiting the RNA polymerase II to the DB complex
  • involved in nucleotide excision repair (ner) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II
  • may be a regulatory protein (Coin 2007)
  • forming a network of interaction with DNA near the transcription start site and facilitating promoter melting, interacting with the priming substrate and thus may act as a transient component of the catalytic site of the initiation complex
  • CELLULAR PROCESS nucleotide, repair, nucleotide excision repair
    nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of RNA polymerase II transcription initiation factor II M
  • component of the core-TFIIH basal transcription factor (one of the six subunits)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with CAK
  • interacting with ERCC3, thus stimulating the ATPase activity of ERCC3 (Coin 2007)
  • GTF2H5 interacts with the GTF2H4 and the GTF2H4-GTF2H5-GFP product is incorporated into TFIIH
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS