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FLASH GENE

Symbol

PRSS2

contributors: mct - updated : 25-07-2006

HGNC name	protease, serine, 2 (trypsin 2)
HGNC id	9483

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional fusion     gain of function PRSS1/PRSS2, exons 1 and 2 are derived from PRSS2 and exons 3-5 from PRSS1, apparently resulted from a non-allelic homologous recombination, with double gain-of-function effect in chronic pancreatitis

Susceptibility

to chronic pancreatitis

Variant & Polymorphism	variant G191R protecting against chronic pancreatitis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS