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FLASH GENE

Symbol

PRSS2

contributors: mct - updated : 25-07-2006

HGNC name	protease, serine, 2 (trypsin 2)
HGNC id	9483

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q35      Physical location : 142.479.907 - 142.481.378
Synonym name	anionic trypsinogene
Synonym symbol(s)	TRY2,T2, TRY8, TRYP2
EC.number	3.4.21.4

DNA

TYPE	functioning gene
STRUCTURE	3.00 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine pancreas       predominantly Lymphoid/Immune thymus       highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

pancreas

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to C.elegans c07g1.1

Homologene

FAMILY

peptidase family S1 or trypsin family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	protease serine,anionic trypsinogen
	preferential cleavage arg-xaa and lys-xaa

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

digestion

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

with PRSS1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional fusion     gain of function PRSS1/PRSS2, exons 1 and 2 are derived from PRSS2 and exons 3-5 from PRSS1, apparently resulted from a non-allelic homologous recombination, with double gain-of-function effect in chronic pancreatitis

Susceptibility

to chronic pancreatitis

Variant & Polymorphism	variant G191R protecting against chronic pancreatitis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS