Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SGK1

contributors: mct/npt/pgu - updated : 04-11-2016

HGNC name	serum/glucocorticoid regulated kinase 1
HGNC id	10810

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in clear cell renal carcinoma with good outcome constitutional       gain of function leading to hypertension but also to enhanced SLC5A1 activity and obesity constitutional     --over   strongly correlates with the occurrence of cell death tumoral somatic mutation       in germinal centre B-cell constitutional       gain of function in Alzheimer disease (AD) constitutional       loss of function SGK1 deficiency impaired platelet tethering, adhesion and thrombus formation

Susceptibility

to blood pressure change over time and strength of the insulin-diastolic blood pressure relationship to type 2 diabetes

Variant & Polymorphism other	polymorphisms increasing the risk of blood pressure change over time and strength of the insulin-diastolic blood pressure relationship
	risk haplotype (I6CC/E8CC/CT) was significantly more frequent in diabetic patients

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cardiovascular atheroma   inhibition of SGK1 activity is a novel therapeutic approach for the treatment of occlusive vascular diseases respiratory lung   may be a potential therapeutic target for the treatment of pulmonary arterial hypertension immunology inflammatory   therapeutic target for the treatment of inflammatory disease

ANIMAL & CELL MODELS