SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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| intracellular,nucleus,nucleoplasm
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| basic FUNCTION
| playing an important role in cellular stress response |
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may be involved in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion |
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capable to regulate the cell surface expression of several metabolite transporters including the insulin-sensitive facilitative glucose transporter SLC2A1 |
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may contributing to the stimulation of cellular glucose uptake by insulin |
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stimulating glucose transport by enhancing the abundance of the facilitative glucose transporter SLC2A4 in the cell membrane at least in part via direct SLC2A4 phosphorylation |
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playing a key role in the molecular pathway of cell death, in which SGK1 seems to exert a protective role |
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having capacity to modulate expression of ion channels and transporters at the plasma membrane of many cell types also providing a means to alter membrane excitability in neurons |
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having multiple functions as a modulator of neuronal plasticity and a mediator of neuronal survival |
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also important in transduction of growth factors and steroid-dependent survival signals and may have a role in the development of resistance to cancer chemotherapy  |
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participates in the stimulation of renal tubular glucose transport in diabetes, the renal profibrotic effect of both angiotensin II and aldosterone, and in fetal programing of arterial hypertension |
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involved in the regulation of epithelial transport through phosphorylation of the ubiquitin protein ligase NEDD4L |
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SGK1/SGK3 are novel potent stimulators of SLC6A19 and may thus participate in the regulation of neutral amino acid transport |
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short-lived protein, predominantly targeted to the endoplasmic reticulum (ER) to undergo rapid proteasome-mediated degradation through the ER-associated degradation (ERAD) system |
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inhibits the NOTCH1 signaling pathway via phosphorylation of FBXW7 |
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highly cytokine-responsive gene in myeloma cells promoting their malignant growth |
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its regulation is important for ensuring uterine receptivity and maintenance of pregnancy |
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activation of platelets by thrombin leads to up-regulation of SGK1 and ORAI1 protein expression, an effect expected to further enhance activation-dependent Ca2+ entry into platelets with subsequent Ca2+-dependent degranulation, adhesion, aggregation and thrombus formation |
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is a positive regulator of constitutive albumin uptake in renal proximal tubule cells |
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neuronal expression of SGK1 in aged human brain and its nuclear compartmentalization suggest a possible neuroprotective role |
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is a mediator for the effects of cortisol on neurogenesis and glucocorticoid receptor (GR) function, with particular relevance to stress and depression |
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likely plays a key role in regulating neutrophil survival signaling |
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is important to the regulation of macrophage activation that contributes to the development of pulmonary arterial hypertension (PAH) |
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growth factor-responsive kinase, having a molecular role in stimulation of VSMC proliferation |
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role for SGK1 in stimulation of arterial VSMC growth via regulation of CTNNB1 dynamics and SGK1 is implicated in the progression of intimal narrowing following arterial injury |
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SGK1 and NDRG1 participate in the regulation of NFKB1 signaling and maturation of dendritic cells (DCs) |
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roles of AKT1 and SGK1 in the regulation of renal tubular transport |
