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FLASH GENE

Symbol

FUT1

contributors: mct - updated : 09-11-2015

HGNC name	fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)
HGNC id	4012

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

H

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         mRNA transcription was lost during differentiation of mesenchymal stem cells (MSCs) constitutional       loss of function FUT1 allele 235C was identified, which greatly diminished the activity of FUT1, associated withVpara-Bombay phenotype ( tumoral         altered expression of fucosylation pathway gene(FUT1), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mouse embryos lacking protein Fut1 die at midgestation with severe defects in somitogenesis, vasculogenesis, cardiogenesis, and neurogenesis