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FLASH GENE
Symbol FUT1 contributors: mct - updated : 09-11-2015
HGNC name fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)
HGNC id 4012
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies ortholog to murine Fut1
ortholog to rattus Fut1
Homologene
FAMILY glycosyltransferase 11 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
text
  • type II membrane protein
  • membrane-bound form in trans cisternae of Golgi
    • basic FUNCTION
  • creating a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway
  • regulating the expression of ABO antigenes in erythrocyte membranes and related antigens in several tissues
  • fucosyltransferase required for the biosynthesis of the terminal glycan motif
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • essential core member of NOTCH signaling pathways in mammals
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other macrophages regulate expression of FUT1 genes in human endometrial epithelial cells, which could contribute to the pathophysiology of primary unexplained infertility in women
    ASSOCIATED DISORDERS
    corresponding disease(s) H
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    mRNA transcription was lost during differentiation of mesenchymal stem cells (MSCs)
    constitutional       loss of function
    FUT1 allele 235C was identified, which greatly diminished the activity of FUT1, associated withVpara-Bombay phenotype (
    tumoral        
    altered expression of fucosylation pathway gene(FUT1), correlated with poor survival in patients with non&8209;small cell lung cancer (NSCLC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse embryos lacking protein Fut1 die at midgestation with severe defects in somitogenesis, vasculogenesis, cardiogenesis, and neurogenesis