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FLASH GENE
Symbol CAT contributors: mct - updated : 19-10-2020
HGNC name catalase
HGNC id 1516
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer homomer , tetramer
HOMOLOGY
interspecies ortholog to murine Cat
ortholog to dog cat
Homologene
FAMILY catalase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,interspace
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,peroxisome
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,lysosome
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • involved in catabolic pathway of activated oxygen species and free radical detoxification
  • catalase overexpression has a protective role against UVB irradiation by preventing DNA damage mediated by the late ROS increase
  • catalase is an antioxidant enzyme the activity of which is crucial for the protection against damage caused by reactive oxygen species
  • heme enzymes, which catalyze decomposition of hydrogen peroxide to water and molecular oxygen
  • is an important antioxidant enzyme that dismutates hydrogen peroxide into water and molecular oxygen
  • catalase is a key enzyme in the metabolism of H2O2 and reactive nitrogen species, and its expression and localization is markedly altered in tumors
  • major peroxisome protein, plays a critical role in removing peroxisome-generated reactive oxygen species (ROS) produced by peroxisome enzymes
  • catalase plays an important role in pexophagy during nutrient deprivation
  • potential therapeutic effects in nonalcoholic fatty liver disease (NAFLD) progression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    heme group and NADP
    protein
  • transcription factors (PPARG,POU2F1), as well as genetic, epigenetic, and posttranscriptional processes, have emerged as crucial contributors to the regulation of catalase expression (PIMID: 26117330)
  • MARVELD1 interacting with CAT regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CAT
    Susceptibility
  • to essential hypertension
  • to noise-induced hearing loss
    • Variant & Polymorphism
    Candidate gene
  • neurocognitive sequelae associated with radiation exposure can be reduced by overexpression of Mitochondrial CAT, operating through a mechanism involving the preservation of neuronal morphology
    • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice devoid of catalase develop an obese, pre-diabetic phenotype