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FLASH GENE

Symbol

IFRD1

contributors: mct/pgu - updated : 06-06-2012

HGNC name	interferon-related developmental regulator 1
HGNC id	5456

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

SCA18

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in a CF (delta F508del) patient-derived bronchial epithelial cell line

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed respiratory CF (mucoviscidosis)   targeting neutrophil effector function through IFRD1 or HDAC1 could be a promising strategy to ameliorate the debilitating chronic lung infections associated with mucoviscidosis (CF) respiratory CF (mucoviscidosis)   targeting airway epithelial cells through IFRD1 might be a new promising strategy to ameliorate the chronic airway inflammation and oxidative stress associated with CF

ANIMAL & CELL MODELS

Ifrd1 gene product is detectable in tracheal epithelium from both newborn and adult F508del-CFTR mice