SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| text
| localized to plasma membranes via N-terminal myristoyl and palmitoyl anchors (myristoylation is required to target RP2 to the basal body, whereas palmitoylation, the interaction of RP2 with ARL3 and the C-terminal domain of RP2 were not essential)  |
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localizes to the ciliary apparatus, namely the basal body and the associated centriole at the base of the photoreceptor cilium |
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in renal epithelia, RP2 localizes to the primary cilium |
| basic FUNCTION
| involved in beta-tubulin folding |
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stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization |
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acting as guanine nucleotide dissociation inhibitor for ARL3 |
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DNA-binding protein that exhibits exonuclease activity, with a preference for single-stranded or nicked DNA substrates that occur as intermediates of base excision repair pathways |
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may have previously unrecognized roles as a DNA damage response factor and 3' to 5' exonuclease |
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may play a role in regulating vesicle traffic and docking |
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playing a role in pericentriolar vesicle trafficking and intraflagellar transport |
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RP2/NSF complex may play an important role in membrane protein trafficking in photoreceptors and other cells of the retina |
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may be an important regulator of ciliary function through its association with polycystin 2 ( |
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essential for ciliary function during vertebrate development ( |
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RP2 and PKD2 function in a common developmental process ( |
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could have a role in the photoreceptor machinery to reduce the stress caused by free GNB1, by sequestering free GNB1 and facilitating the assembly and membrane association of the GNB1:GNG1 heterodimer |
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RP2 and ARL3 regulate the trafficking of specific kinesins to cilia tips |
