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FLASH GENE

Symbol

RPL10

contributors: mct - updated : 13-11-2015

HGNC name	ribosomal protein L10
HGNC id	10298

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	gene in gene
text	small nucleolar RNA U70 (SNORA70) embedded in the fifth intron
STRUCTURE	4.11 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006013 7 - 2335 NP_006004 - 214 - 2008 18258260 NM_001256577 7 - 2172 NP_001243506 - 216 - 2008 18258260 NM_001256580 6 - 2227 NP_001243509 - 178 - 2008 18258260

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pancreas exocrine       highly   stomach       highly Lymphoid/Immune tonsils       predominantly Reproductive female system uterus cervix   moderately   female system breast mammary gland   moderately   male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Connective bone     moderately Epithelial secretory glandular endocrine   Lymphoid         Muscular       moderately

cell lineage
cell lines
fluid/secretion	moderately in blood, highly in lymph

at STAGE

physiological period

fetal

Text	moderately in umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

RiboP

HOMOLOGY

interspecies	homolog to rattus Rpl10 (99.5 pc)
	homolog to murine Rpl10 (99.5 pc)

intraspecies

homolog to highly to the JUN binding protein JIF-1 which inhibits the formation of JUN dimers

Homologene

FAMILY

ribosomal protein L10E family

CATEGORY

structural protein , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,ribosome
text	cytosolic large ribosomal subunit

basic FUNCTION	acting as a structural constituant of 60S ribosomal subunit
	acting as a transcription cofactor inhibiting the activity of AP-1 transcription factors
	multifunctional component of the large ribosomal subunit, involved in ribosome biogenesis and function

CELLULAR PROCESS	nucleotide, transcription, regulation
	protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

protein

signaling

signal transduction

potentially involved in signal transduction pathways involving SH3 containing protein

a component

component of the 60S ribosomal subunit

INTERACTION

DNA

RNA

binding

small molecule

protein	YES1
	RPL10L plays an essential role during the meiotic stage of spermatogenesis by compensating for meiotic sex chromosome inactivation (MSCI)-mediated transcriptional silencing of RPL10

cell & other

REGULATION

Other

down-regulated during adipocyte, kidney, and heart differentiation

ASSOCIATED DISORDERS

corresponding disease(s)

AUTSX5 , MRXS35

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   decreased expression may be associated with early development of prostate cancer tumoral     --over   but later a high level of may facilitate progression of the tumors to a more aggressive phenotype constitutional         mental retardation tumoral somatic mutation       in T-cell acute lymphoblastic leukemia

Susceptibility

to autism spectrum disorder, AUTSX5

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS