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FLASH GENE
Symbol RPL10 contributors: mct - updated : 13-11-2015
HGNC name ribosomal protein L10
HGNC id 10298
Corresponding disease
AUTSX5 autism, susceptibility to, X-linked 5
MRXS35 mental retardation, X-linked, syndromic, 35
Location Xq28      Physical location : 153.626.570 - 153.630.680
Synonym name
  • Wilm's tumor related protein
  • tumor suppressor QM
  • laminin receptor homolog
  • 60S ribosomal protein L10
  • Synonym symbol(s) GSR1, DXS648, QM, NOV, DXS648E
    DNA
    TYPE functioning gene
    SPECIAL FEATURE gene in gene
    text small nucleolar RNA U70 (SNORA70) embedded in the fifth intron
    STRUCTURE 4.11 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    MECP2 Xq28 methyl CpG binding protein 2 (Rett syndrome) OPN1LW Xq28 opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan) OPN1MW Xq28 opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) CXorf2 Xq28 chromosome X open reading frame 2 TKTL1 Xq28 transketolase-like 1 FLNA Xq28 filamin A, alpha (actin binding protein 280) EMD Xq28 emerin (Emery-Dreifuss muscular dystrophy) RPL10 Xq28 ribosomal protein L10 DNASE1L1 Xq28 deoxyribonuclease I-like 1 TAZ Xq28 tafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome) ATP6AP1 Xq28 ATPase, H+ transporting, lysosomal accessory protein 1 GDI1 Xq28 GDP dissociation inhibitor 1 DXS9928E Xq28 DNA segment on chromosome X (unique) 9928 expressed sequence PLXN3 Xq28 likely ortholog of mouse plexin 3 DXS9879E Xq28 DNA segment on chromosome X (unique) 9879 expressed sequence UBL4 Xq28 ubiquitin-like 4 SLC10A3 Xq28 solute carrier family 10 (sodium/bile acid cotransporter family), member 3 FAM3A Xq28 family with sequence similarity 3, member A G6PD Xq28 glucose-6-phosphate dehydrogenase IKBKG Xq28 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2335 - 214 - 2008 18258260
    7 - 2172 - 216 - 2008 18258260
    6 - 2227 - 178 - 2008 18258260
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   highly
     stomach   highly
    Lymphoid/Immunetonsils   predominantly
    Reproductivefemale systemuteruscervix moderately
     female systembreastmammary gland moderately
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectivebone  moderately
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    Muscular   moderately
    cell lineage
    cell lines
    fluid/secretion moderately in blood, highly in lymph
    at STAGE
    physiological period fetal
    Text moderately in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated RiboP
    HOMOLOGY
    interspecies homolog to rattus Rpl10 (99.5 pc)
    homolog to murine Rpl10 (99.5 pc)
    intraspecies homolog to highly to the JUN binding protein JIF-1 which inhibits the formation of JUN dimers
    Homologene
    FAMILY
  • ribosomal protein L10E family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • cytosolic large ribosomal subunit
  • basic FUNCTION
  • acting as a structural constituant of 60S ribosomal subunit
  • acting as a transcription cofactor inhibiting the activity of AP-1 transcription factors
  • multifunctional component of the large ribosomal subunit, involved in ribosome biogenesis and function
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism protein
    signaling signal transduction
  • potentially involved in signal transduction pathways involving SH3 containing protein
  • a component
  • component of the 60S ribosomal subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein YES1
    cell & other
    REGULATION
    Other down-regulated during adipocyte, kidney, and heart differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s) AUTSX5 , MRXS35
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    decreased expression may be associated with early development of prostate cancer
    tumoral     --over  
    but later a high level of may facilitate progression of the tumors to a more aggressive phenotype
    constitutional        
    mental retardation
    tumoral somatic mutation      
    in T-cell acute lymphoblastic leukemia
    Susceptibility to autism spectrum disorder, AUTSX5
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS