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FLASH GENE
Symbol TCF21 contributors: mct - updated : 06-07-2020
HGNC name transcription factor 21
HGNC id 11632
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
basic helix-loop-helix (HLH) motif protein
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Pod-1
Homologene
FAMILY basic helix-loop-helix family
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium
  • critical role for TCF21 in the differentiation and maintenance of podocytes
  • TCF21 may affect coronary artery disease risk through interaction with other disease associated loci
  • TCF21 functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC) progression
  • in contrast to TCF21 which is protective toward coronary artery disease (CAD), SMAD3 expression in human coronary artery smooth muscle cells (HCASMC) was shown to be directly correlated with disease risk
  • has distinct roles in the cap mesenchyme and stromal mesenchyme compartments during kidney development, suggesting that TCF21 regulates key molecular pathways required for branching morphogenesis
  • TCF21 suppresses in vivo tumor-associated angiogenesis
  • TCF21 promotes the transcription of LPL by directly binding to the E-box motif in the LPL promoter
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text embryonic development, mesoderm development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to E-box (5'-CANNTG-3')
    RNA
    small molecule
    protein
  • e12 and e47
  • SRY acts directly on the TCF21 promoter to in part initiate a cascade of events associated with Sertoli cell differentiation and embryonic testis development
  • promotes proinflammatory IL6 expression and extracellular matrix remodeling in visceral adipose stem cells
  • TCF21 is a novel regulator of preadipocyte differentiation, in part by directly promoting LPL expression
  • TCF21 blocks MYOCD and SRF association by direct TCF21-MYOCD interaction in smooth muscle cell differentiation
    • cell & other
    REGULATION
    Other autophagy may also play an important role in regulation TCF21 expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in cholangiocarcinoma (CCA)
    tumoral     --over  
    by demethylation led to remarkable decreases of cell viability and invasion ability but an increase of cell apoptosis in lung cancer
    tumoral     --over  
    through promoter hypermethylation in colorectal cancer (CRC) development
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS