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FLASH GENE

Symbol

TCF21

contributors: mct - updated : 06-07-2020

HGNC name	transcription factor 21
HGNC id	11632

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	6.42 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_198392 2 - 3216 NP_938206 - 179 - 2019 31014396 NM_003206 2 - 1280 NP_003197 - 179 - 2019 31014396

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Cardiovascular heart         Reproductive male system testis       Urinary kidney nephron renal capsule glomerulus   Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Membrane         Membrane serous pericardiium     Muscular striatum cardiac

cells

System Cell Pubmed Species Stage Rna symbol Urinary podocyte Homo sapiens Adult Urinary podocyte Homo sapiens Fetal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	mesenchymal and glomerular epithelial cells in the developing kidney,placenta,mesoderm

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

basic helix-loop-helix (HLH) motif protein

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine Pod-1

Homologene

FAMILY

basic helix-loop-helix family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	functions as a transcriptional repressor to regulate proepicardial cell specification and the correct formation of a mature epithelial epicardium
	critical role for TCF21 in the differentiation and maintenance of podocytes
	TCF21 may affect coronary artery disease risk through interaction with other disease associated loci
	TCF21 functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC) progression
	in contrast to TCF21 which is protective toward coronary artery disease (CAD), SMAD3 expression in human coronary artery smooth muscle cells (HCASMC) was shown to be directly correlated with disease risk
	has distinct roles in the cap mesenchyme and stromal mesenchyme compartments during kidney development, suggesting that TCF21 regulates key molecular pathways required for branching morphogenesis
	TCF21 suppresses in vivo tumor-associated angiogenesis
	TCF21 promotes the transcription of LPL by directly binding to the E-box motif in the LPL promoter

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

text	embryonic development, mesoderm development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to E-box (5'-CANNTG-3')

RNA

small molecule

protein	e12 and e47
	SRY acts directly on the TCF21 promoter to in part initiate a cascade of events associated with Sertoli cell differentiation and embryonic testis development
	promotes proinflammatory IL6 expression and extracellular matrix remodeling in visceral adipose stem cells
	TCF21 is a novel regulator of preadipocyte differentiation, in part by directly promoting LPL expression
	TCF21 blocks MYOCD and SRF association by direct TCF21-MYOCD interaction in smooth muscle cell differentiation

cell & other

REGULATION

Other

autophagy may also play an important role in regulation TCF21 expression

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in cholangiocarcinoma (CCA) tumoral     --over   by demethylation led to remarkable decreases of cell viability and invasion ability but an increase of cell apoptosis in lung cancer tumoral     --over   through promoter hypermethylation in colorectal cancer (CRC) development

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS