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FLASH GENE
Symbol F2RL2 contributors: npt/mct - updated : 23/12/2008
HGNC name coagulation factor II (thrombin) receptor-like 2
HGNC id 3539
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor including a sequence with F2RL3 in the extracellular domain
  • multiple PDZ domains (second PDZ domain binds to phosphatidylinositol (PI) lipid membranes with high affinity) (Wu 2007)
    • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine F2rl2
    homolog to C.elegans T22D1.12
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins
  • member of the protease-activated receptor family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cofactor for F2RL3 activation by thrombin
  • mediating thrombin-triggered phosphoinositide hydrolysis
  • thrombin receptor
  • able to signal autonomously to induce IL8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses
  • involved in the invasive phase of placentation
  • required for polarity in diverse cell types (Wu 2007)
  • ideal scaffold protein for integrating PIP signaling events during cellular polarization (Wu 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    text blood coagulation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with F2R (critical determinant of F2R function, targeting of F2RL2 may mitigate the effects of F2R in activating endothelial responses such as vascular inflammation)
  • interacting with F2RL3
    • cell & other
    REGULATION
    activated by proteases including thrombin, proteolytic cleavage of its extracellular N terminus, generating a new receptor N terminus which functions as a tethered ligand and activates the receptor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mice deficient in Par3 (Kahn, 1998)