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FLASH GENE

Symbol

F2RL2

contributors: npt/mct - updated : 23/12/2008

HGNC name	coagulation factor II (thrombin) receptor-like 2
HGNC id	3539

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q13      Physical location : 75.911.307 - 75.919.240
Synonym name	protease-activated receptor 3
	thrombin receptor-like 2
Synonym symbol(s)	PAR3, PAR-3

DNA

TYPE	like-sequence
STRUCTURE	7.93 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed F2RL2 2 - 3427 42 374 - Ostrowska (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Respiratory respiratory tract trachea     highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic megakaryocyte Blood/Hematopoietic platelet Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane segments (7TM) receptor including a sequence with F2RL3 in the extracellular domain
	multiple PDZ domains (second PDZ domain binds to phosphatidylinositol (PI) lipid membranes with high affinity) (Wu 2007)

conjugated

GlycoP

HOMOLOGY

interspecies	ortholog to murine F2rl2
	homolog to C.elegans T22D1.12

Homologene

FAMILY	G protein coupled receptor superfamily
	member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins
	member of the protease-activated receptor family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	cofactor for F2RL3 activation by thrombin
	mediating thrombin-triggered phosphoinositide hydrolysis
	thrombin receptor
	able to signal autonomously to induce IL8 release mediated by ERK1/2 phosphorylation, which contributes actively to inflammatory responses
	involved in the invasive phase of placentation
	required for polarity in diverse cell types (Wu 2007)
	ideal scaffold protein for integrating PIP signaling events during cellular polarization (Wu 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

coagulation/hemostasis

text	blood coagulation

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interaction with F2R (critical determinant of F2R function, targeting of F2RL2 may mitigate the effects of F2R in activating endothelial responses such as vascular inflammation)
	interacting with F2RL3

cell & other

REGULATION

activated by

proteases including thrombin, proteolytic cleavage of its extracellular N terminus, generating a new receptor N terminus which functions as a tethered ligand and activates the receptor

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mice deficient in Par3 (Kahn, 1998)