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FLASH GENE
Symbol TIMP4 contributors: - updated : 05-05-2004
HGNC name tissue inhibitor of metalloproteinase 4
HGNC id 11823
Location 3p25      Physical location : 12.194.572 - 12.200.647
DNA
TYPE functioning gene
SPECIAL FEATURE gene in gene
text maybe embedded in intron V of SYN2
STRUCTURE 5.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
12 cysteine residues that form six disulfide bridges
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY TIMP family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • matrix metalloproteinase, tissue inhibitor 4
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding MMPs in a 1:1 stoechiometry
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS