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FLASH GENE
Symbol RGS14 contributors: mct - updated : 14-02-2011
HGNC name regulator of G-protein signaling 14
HGNC id 9996
Location 5q35.3      Physical location : 176.784.843 - 176.799.598
DNA
TYPE functioning gene
STRUCTURE 14.76 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map D5S2006 - RGS14 - qter
RNA
TRANSCRIPTS type messenger
text three isoforms produced by alternative splicing
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2418 61.32 566 - 2005 15917656
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Lymphoid/Immunespleen   moderately
Nervousbrainlimbic systemhippocampus moderately Homo sapiens
Reproductivefemale systemovary  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RGS domain with three conserved motifs GH1, GH2, GH3
  • two Raf-like Ras-binding domains (RBDs), a tandem (R1, R2) Ras binding domain (RBD), first Ras-binding domain is sufficient to target RGS14 to centrosomes
  • a GPR/GoLoco (GL) domain that forms a stable complex with inactive GNAI11/GNAI3-GDP,(importance of its interactions with GNAI1 in determining RGS14 subcellular localization and linked functions)
  • a C terminal coiled-coil domain
  • HOMOLOGY
    interspecies homolog to C.elegans EGL-10
    homolog to yeast SST2
    homolog to murine Rgs14
    homolog to rattus Rgs14
    Homologene
    FAMILY
  • regulator of G protein signaling gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text centrosomal and nuclear cytoplasmic shuttling protein
    basic FUNCTION
  • functioning as GTPase-activating protein for G protein alpha i and q subunits
  • inhibiting signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
  • implicated in a diverse set of cellular processes including centrosome and nuclear functions and stress-induced signaling pathways
  • microtubule-associated protein and a component of the mitotic spindle that may regulate microtubule polymerization and spindle organization
  • its activity towards G-protein alpha subunits is independent of its binding to RAP2A
  • facilitates the formation of a selective RAS.GTP-Raf-MEK-ERK multiprotein complex to promote sustained ERK activation and regulate HRAS-dependent neuritogenesis
  • integrator of G protein and MAPKinase signalling pathways
  • newly appreciated integrator of G protein and Ras/Raf signalling pathways
  • scaffolding protein that integrates G protein and HRAS/ERK/MAP kinase signaling pathways
  • key regulator of signaling pathways linking synaptic plasticity in CA2 pyramidal neurons to hippocampal-based learning and memory
  • brain scaffolding protein that integrates G protein and MAP kinase signaling pathways
  • with RIC8A are recruited from the cytosol to the plasma membrane in the presence of coexpressed GNAI1 in cells, suggesting formation of a functional protein complex with GNAI1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to RAP2A
  • binds and regulates the subcellular localization and activities of HRAS and Raf kinases in cells
  • RGS14 and RIC8A share an overlapping binding region within the last 11 amino acids of GNAI1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    mental retardationother 
    inhibition of RGS14 function may serve as an attractive therapeutic target for future cognitive enhancers
    ANIMAL & CELL MODELS