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FLASH GENE

Symbol

RGS12

contributors: npt/ - updated : 03-03-2007

HGNC name	regulator of G-protein signaling 12
HGNC id	9994

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal PDZ (PSD-95/Dlg/ZO-1) domain
	a RGS domain (120AA) with three conserved motifs GH1, GH2, GH3
	a C terminal coiled-coil domain
	a PID domain
	a GOLOCO domain
	two RBD(ras-binding) domains

HOMOLOGY

interspecies	homolog to C.elegans EGL-10
	homolog to yeast SST2

Homologene

FAMILY

CATEGORY

regulatory , receptor membrane G

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor
	negative regulator of G protein signaling 12, functioning as GTPase-activating protein for G protein alpha i and q subunits

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

through its PTB domain with the tyrgine-phosphorylated N-type calcium channel

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS