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FLASH GENE
Symbol RGS12 contributors: npt/ - updated : 03-03-2007
HGNC name regulator of G-protein signaling 12
HGNC id 9994
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveesophagus   highly
Nervousnervecranial nerve  highly
Reproductivemale systemprostate   
Urinarykidney    
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal PDZ (PSD-95/Dlg/ZO-1) domain
  • a RGS domain (120AA) with three conserved motifs GH1, GH2, GH3
  • a C terminal coiled-coil domain
  • a PID domain
  • a GOLOCO domain
  • two RBD(ras-binding) domains
  • HOMOLOGY
    interspecies homolog to C.elegans EGL-10
    homolog to yeast SST2
    Homologene
    FAMILY
    CATEGORY regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor
  • negative regulator of G protein signaling 12, functioning as GTPase-activating protein for G protein alpha i and q subunits
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • through its PTB domain with the tyrgine-phosphorylated N-type calcium channel
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS